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Topic Summary

Posted by: Sergio
« on: March 23, 2013, 12:15:56 PM »

From: http://www.sciencebasedmedicine.org/index.php/collagen-an-implausible-supplement-for-joint-pain/

I’m one of those odd people that enjoys distance running. I end up spending a lot of time in the company of other runners. And when we’re not running, we’re usually griping about our running injuries. As the cohort that I run with ages, the injuries are getting more prevalent. Besides the acute conditions, the chronic problems are starting to appear. Our osteoarthritis years are here.
As the available pharmacist, I get a lot of questions about joint pain. What’s reassuring, I tell them, is that they shouldn’t blame running. Osteoarthritis is common — the most frequent cause of joint pain. For some, it starts in our twenties, and by our seventies, osteoarthritis is virtually certain. Regardless of your level of exercise, the passage of time means the classic osteoarthritis symptoms — joint pain and morning stiffness, that worsens over time.
Osteoarthritis progresses gradually. Blame biomechanics and biochemistry. It starts with a breakdown of the cartilage matrix. Stage 2 progresses to erosion of the cartilage and a release of collagen fragments. Stage 3 is a chronic inflammatory response. The goals of treatment are to reduce inflammation and pain, and stop progressive disease. There’s no drug therapy that’s been show to actually improve joint function. Reduce pain, or slow inflammation, yes. Analgesics, like Tylenol, and anti-inflammatories are mainstays. But repair damage? Sorry: you lose it, it’s gone. Chondrocytes don’t seem to be able to repair the overall matrix — which is made mainly of collagen
Posted by: Sergio
« on: March 23, 2013, 12:02:36 PM »

In non-injured ligaments or tendons, collagen fibers are flexible and have some elasticity. But, they are not supposed to stretch very far. Injuries can stretch these fibers beyond their designed lengths. Or, wear and tear through repetitive motion can fray or tear them. When these tissues are stretched beyond their normal limits, wear out, or tear, pain is perceived.
Inflammation produces pain, which is a sign the body’s healing process is occurring. So initially, inflammation occurs as the body tries to heal the damage. Since the tendons and ligaments have a poor and limited blood supply, it is important not to shut down the initial inflammatory response. Shutting down the inflammation is equivalent to shutting down the healing cycle and YOU prevent yourself from healing correctly. In all cases that require Prolotherapy, the ligaments and tendons, whether through the use of anti-inflammatories, or because of a weakened immune system, or because of the severity of the injury, did not heal sufficiently. Injured, loose, or stretched out ligaments are often referred to as the condition of ligament relaxation, or ligament laxity. This is what produces the pain and discomfort, especially with movement because the connection of the ligament or tendon to the bone may be inflamed and the joint may move beyond its normal range of motion.